2024
Zwanenburg, Price, Löck (2024)
Artificial intelligence for response prediction and personalisation in radiation oncology
Strahlenther Onkol: published online.
Starke, Kieslich, Palkowitsch, Hennings, Troost, Krause, Bensberg, Hahn, Heinzelmann, Bäumer, Lühr, Timmermann, Löck (2024)
A deep-learning-based surrogate model for Monte-Carlo simulations of the linear energy transfer in primary brain tumor patients treated with proton-beam radiotherapy
Phys Med Biol: published online.
Zwanenburg, Löck (2024)
MIRP: A Python package for standardised radiomics
Journal of Open Source Software 9(99): 6413.
Kirchner, Plesca, Rothe, Resag, Löck, Bene, Rupp, Linge, Wehner, Krause, Schmitz (2024)
Type I conventional dendritic cells and CD8+ T cells predict favorable clinical outcome of head and neck squamous cell carcinoma patients
Front Immunol 15: 1414298.
Witzmann, Raschke, Wesemann, Löck, Funer, Linn, Troost (2024)
Diffusion decrease in normal-appearing white matter structures following photon or proton irradiation indicates differences in regional radiosensitivity
Radiother Oncol 199: 110459.
Loutfi, Podasca, Zwanenburg, Upadhaya, Barrios, Raleigh, Chen, Capaldi, Zheng, Gevaert, Wu, Silva, Zhang, Bai, Seuntjens, Löck, Richard, Morin, Reinhold, Lepage, Vallières (2024)
Unraveling Radiomics Complexity: Strategies for Optimal Simplicity in Predictive Modeling
arXiv:2407.04888 [eess.IV].
Igbo, Jentsch, Linge, Plesca, Kuzay, Löck, Kumaravadivel, Doms, Stolz-Kieslich, Pollack, Brückmann, Tittlbach, Weitz, Aust, Apolle, Schmitz, Troost (2024)
Correlation of microscopic tumor extension with tumor microenvironment in esophageal cancer patients
Strahlenther Onkol 200: 595-604.
Horst, Bodenstein, Brand, Hans, Karsch, Lessmann, Löck, Schürer, Pawelke, Beyreuther (2024)
Dose and dose rate dependence of the tissue sparing effect at ultra-high dose rate studied for proton and electron beams using the zebrafish embryo model
Radiother Oncol 194: 110197.
Shahzadi, Seidlitz, Beuthien-Baumann, Zwanenburg, Platzek, Kotzerke, Baumann, Krause, Troost, Löck (2024)
Radiomics for residual tumour detection and prognosis in newly diagnosed glioblastoma based on postoperative [11C] methionine PET and T1c-w MRI
Sci Rep 14: 4576.
Schniewind, Besso, Klicker, Schwarz, Hadiwikarta, Richter, Löck, Linge, Krause, Dubrovska, Baumann, Kurth, Peitzsch (2024)
Epigenetic Targeting to Overcome Radioresistance in Head and Neck Cancer
Cancers 16: 730.
Whybra, Zwanenburg, Andrearczyk, Schaer, Apte, Ayotte, Baheti, Bakas, Bettinelli, Boellaard, Boldrini, Buvat, Cook, Dietsche, Dinapoli, Gabryś, Goh, Guckenberger, Hatt, Hosseinzadeh, Iyer, Lenkowicz, Loutfi, Löck, Marturano, Morin, Nioche, Orlhac, Pati, Rahmim, Masoud Rezaeijo, Rookyard, Salmanpour, Schindele, Shiri, Spezi, Tanadini-Lang, Tixier, Upadhaya, Valentini, van Griethuysen, Yousefirizi, Zaidi, Müller, Vallières, Depeursinge (2024)
The Image Biomarker Standardization Initiative: Standardized Convolutional Filters for Reproducible Radiomics and Enhanced Clinical Insights
Radiology 310: e231319.
Giehl-Brown, Geipel, Löck, Dehlke, Schweipert, Weitz, Riediger (2024)
Transfusions of packed red blood cells in surgery for liver cancer: predictor of impaired overall survival but not recurrence-free survival – Impact of blood transfusions in liver surgery
J Gastrointest Surg 28: 402-411.
Linge, Patil, Grosser, Lohaus, Gurtner, Kemper, Gudziol, Haim, Nowak, Tinhofer, Zips, Guberina, Stuschke, Balermpas, Rödel, Schäfer, Grosu, Abdollahi, Debus, Ganswindt, Belka, Pigorsch, Combs, Boeke, Gani, Jöhrens, Baretton, Löck, Baumann, Krause (2024)
The value of subcutaneous xenografts for individualised radiotherapy in HNSCC: robust gene signature correlates with radiotherapy outcome in patients and xenografts
Radiother Oncol 191: 110055.
Kocak, D’Antonoli, Mercaldo, Alberich-Bayarri, Baessler, Ambrosini, Andreychenko, Bakas, Beets-Tan, Bressem, Buvat, Cannella, Cappellini, Cavallo, Chepelev, Chu, Demircioglu, deSouza, Dietzel, Fanni, Fedorov, Fournier, Giannini, Girometti, Groot Lipman, Kalarakis, Kelly, Klontzas, Koh, Kotter, Lee, Maas, Marti-Bonmati, Müller, Obuchowski, Orlhac, Papanikolaou, Petrash, Pfaehler, Pinto dos Santos, Ponsiglione, Sabater, Sardanelli, Seeböck, Sijtsema, Stanzione, Traverso, Ugga, Vallières, van Dijk, van Griethuysen, van Hamersvelt, van Ooijen, Vernuccio, Wang, Williams, Witowski, Zhang, Zwanenburg, Cuocolo (2024)
METhodological RadiomICs Score (METRICS): a quality scoring tool for radiomics research endorsed by EuSoMII
Insight Imaging 15: 8.
Baumann, Bacchus, Aznar, Coppes, Deutsch, Georg, Haustermans, Hoskin, Krause, Lartigau, Lee, Löck, Offersen, Thwaites, van der Heide, Valentini, Overgaard (2024)
Clinical research for global needs of radiation oncology
Radiother Oncol 190: 110076.
Weiß, Löck, Xu, Liao, Hoffmann, Troost (2024)
Prediction of radiation pneumonitis using the effective α/β of lungs and heart in NSCLC patients treated with proton beam therapy
Radiother Oncol 190: 110013.
Schön, Kieslich, Nebelung, Riediger, Hoffmann, Zwanenburg, Löck, Kühn (2024)
Comparative analysis of radiomics and deep-learning algorithms for survival prediction in hepatocellular carcinoma
Sci Rep 14: 590.
Gorodetska, Offermann, Püschel, Lukiyanchuk, Gaete, Kurzyukova, Freytag, Haider, Fjeldbo, Di Gaetano, Schwarz, Patil, Borkowetz, Erb, Baniahmad, Mircetic, Lyng, Löck, Linge, Lange, Knopf, Wielockx, Krause, Perner, Dubrovska (2024)
ALDH1A1 drives prostate cancer metastases and radioresistance by interplay with AR- and RAR-dependent transcription
Theranostics 14: 714-737.
2023
Schellhammer, Meric, Löck, Kögler (2023)
Hybrid treatment verification based on prompt gamma rays and fast neutrons: multivariate modelling for proton range determination
Front Phys 11: 1295157.
Metzkes-Ng, Brack, Kroll, Bernert, Bock, Bodenstein, Brand, Cowan, Gebhardt, Hans, Helbig, Horst, Jansen, Kraft, Krause, Leßmann, Löck, Pawelke, Püschel, Reimold, Rehwald, Richter, Schlenvoigt, Schramm, Schürer, Seco, Szabó, Umlandt, Zeil, Ziegler, Beyreuther (2023)
The DRESDEN PLATFORM is a research hub for ultra-high dose rate radiobiology
Sci Rep 13: 20611.
Starke, Zwanenburg, Leger, Lohaus, Linge, Kalinauskaite, Tinhofer, Guberina, Guberina, Balermpas, von der Grün, Ganswindt, Belka, Peeken, Combs, Boeke, Zips, Richter, Troost, Krause, Baumann, Löck (2023)
Multitask Learning with Convolutional Neural Networks and Vision Transformers Can Improve Outcome Prediction for Head and Neck Cancer Patients
Cancers 15: 4897.
Koi, Bitto, Weise, Möbius, Linge, Löck, Yaromina, Besso, Valentini, Pfeifer, Overgaard, Zips, Kurth, Krause, Baumann (2023)
Prognostic biomarkers for the response to the radiosensitizer nimorazole combined with RCTx: a pre-clinical trial in HNSCC xenografts
J Transl Med 21: 576.
Kocak, Baessler, Bakas, Cuocolo, Fedorov, Maier-Hein, Mercaldo, Müller, Orlhac, Pinto dos Santos, Stanzione, Ugga, Zwanenburg (2023)
CheckList for EvaluAtion of Radiomics research (CLEAR): a step-by-step reporting guideline for authors and reviewers endorsed by ESR and EuSoMII
Insights Imaging 14: 75.
Viganò, Ammirabile, Zwanenburg (2023)
Radiomics in liver surgery: defining the path toward clinical application
Updates Surg 75: 1387-1390.
Elkhamisy, Valentini, Lattermann, Radhakrishna, Künzel, Löck, Troost (2023)
Normo- or Hypo-Fractionated Photon or Proton Radiotherapy in the Management of Locally Advanced Unresectable Pancreatic Cancer: A Systematic Review
Cancers 15: 3771.
Zwanenburg (2023)
Standardisation and harmonisation efforts in quantitative imaging
Eur Radiol 33: 8842-8843.
Bhasker, Kolbinger, Skorobohach, Zwanenburg, Löck, Weitz, Hoffmann, Distler, Speidel, Leger, Kühn (2023)
Prediction of clinically relevant postoperative pancreatic fistula using radiomic features and preoperative data
Sci Rep 13: 7506.
Berthold, Pietsch, Piplack, Khamfongkhruea, Thiele, Hölscher, Janssens, Smeets, Traneus, Löck, Stützer, Richter (2023)
Detectability of anatomical changes with prompt-gamma imaging: First systematic evaluation of clinical application during prostate-cancer proton therapy: Detectability of anatomical changes with PGI
Int J Radiat Oncol Biol Phys 117: 718-729.
Baumann, Bacchus, Aznar, Coppes, Deutsch, Georg, Haustermans, Hoskin, Krause, Lartigau, Lee, Löck, Offersen, Overgaard, Thwaites, van der Kogel, van der Heide, Valentini (2023)
ARE HYBRID CONFERENCES THE NEW STANDARD?
Radiother Oncol 184: 109695.
Tawk, Rein, Schwager, Knoll, Wirkner, Hörner-Rieber, Liermann, Kurth, Balermpas, Roedel, Linge, Loeck, Lohaus, Tinhofer, Krause, Stuschke, Grosu, Zips, Combs, Belka, Stenzinger, Herold-Mende, Baumann, Schirmacher, Debus, Abdollahi (2023)
DNA-Methylome based Tumor Hypoxia Classifier Identifies HPV-negative Head & Neck Cancer Patients at Risk for Locoregional Recurrence After Primary Radiochemotherapy
Clin Cancer Res 29: 3051–3064.
Maier, Vehreschild, Uhl, Meyer, Berger-Thürmel, Boerries, Braren, Grünwald, Hadaschik, Palm, Singer, Stuschke, Juárez, Delpy, Lambarki, Hummel, Engels, Andreas, Gökbuget, Ihrig, Burock, Keune, Eggert, Keilholz, Schulz, Büttner, Löck, Krause, Esins, Ressing, Schuler, Brandts, Brucker, Husmann, Oellerich, Metzger, Voigt, Illert, Theobald, Kindler, Sudhof, Reckmann, Schwinghammer, Nasseh, Weichert, von Bergwelt-Baildon, Bitzer, Malek, Öner, Schulze-Osthoff, Bartels, Haier, Ammann, Schmidt, Guenther, Janning, Kasper, Loges, Stilgenbauer, Kuhn, Tausch, Runow, Kerscher, Neumann, Breu, Lablans, Serve (2023)
Profile of the multicenter cohort of the German Cancer Consortium’s Clinical Communication Platform
Eur J Epidemiol 38: 573-586.
Spohn, Schmidt-Hegemann, Ruf, Mix, Benndorf, Bamberg, Makowski, Kirste, Rühle, Nouvel, Sprave, Vogel, Galitsnaya, Gschwend, Gratzke, Stief, Löck, Zwanenburg, Trapp, Bernhardt, Nekolla, Li, Belka, Combs, Eiber, Unterrainer, Unterrainer, Bartenstein, Grosu, Zamboglou, Peeken (2023)
Development of PSMA-PET-guided CT-based radiomic signature to predict biochemical recurrence after salvage radiotherapy
J Nucl Med Mol Imaging 50: 2537–2547.
Valentini, Ebert, Koi, Pfeifer, Löck, Erdmann, Krause, Baumann (2023)
Preclinical trial comparing radiotherapy alone versus standard radiochemotherapy in three human papilloma virus (HPV) negative and three HPV-positive head and neck squamous cell carcinoma (HNSCC) xenograft tumour models
Radiother Oncol 183: 109546.
Witzmann, Raschke, Löck, Wesemann, Krause, Linn, Troost (2023)
Unchanged perfusion in normal-appearing white and grey matter of glioma patients nine months after proton beam irradiation
Acta Oncologica 62: 141-149.
Beyreuther, Horst, Brand, Hans, Karsch, Lessmann, Löck, Schürer, Pawelke (2023)
In Regard to Böhlen et al., Zebrafish Embryo Model of the FLASH Effect
Int J Radiat Oncol Biol Phys 115: 1006-1007.
Klusa, Lohaus, Franken, Baumbach, Cojoc, Dowling, Linge, Offermann, Löck, Hušman, Rivandi, Polzer, Freytag, Lange, Neubauer, Kücken, Perner, Hölscher, Dubrovska, Krause, Kurth, Baumann, Peitzsch (2023)
Dynamics of CXCR4 positive circulating tumor cells in prostate cancer patients during radiotherapy
Int J Cancer 152: 2639-2654.
Starke, Zwanenburg, Leger, Zöphel, Kotzerke, Krause, Baumann, Troost, Löck (2023)
Longitudinal and Multimodal Radiomics Models for Head and Neck Cancer Outcome Prediction
Cancers 15: 673.
Offersen, Aznar, Bacchus, Coppes, Deutsch, Georg, Haustermans, Hoskin, Krause, Lartigau, Lee, Löck, Thwaites, van der Kogel, van der Heide, Valentini, Overgaard, Baumann (2023)
The role of ESTRO guidelines in achieving consistency and quality in clinical radiation oncology practice
Radiother Oncol 179: 109446.
Eulitz, Troost, Klünder, Raschke, Hahn, Schulz, Seidlitz, Thiem, Karpowitz, Hahlbohm, Grey, Engellandt, Löck, Krause, Lühr (2023)
Increased relative biological effectiveness and periventricular radiosensitivity in proton therapy of glioma patients
Radiother Oncol 178: 109422.
Pietsch, Khamfongkhruea, Berthold, Janssens, Stützer, Löck, Richter (2023)
Automatic detection and classification of treatment deviations in proton therapy from realistically simulated prompt gamma imaging data
Med Phys 50: 506-517.
Hatt, Krizsan, Rahmim, Bradshaw, Costa, Forgacs, Seifert, Zwanenburg, El Naqa, Kinahan, Tixier, Jha, Visvikis (2023)
Joint EANM/SNMMI guideline on radiomics in nuclear medicine
Eur J Nucl Med Mol Imaging 50: 352-375.
2022
Dutz, Zwanenburg, Langendijk, Löck (2022)
Modelling for Radiation Treatment Outcome
In: Troost, E.G.C. (eds) Image-Guided High-Precision Radiotherapy. Springer, Cham.
Rabasco Meneghetti, Zwanenburg, Linge, Lohaus, Grosser, Baretton, Kalinauskaite, Tinhofer, Guberina, Stuschke, Balermpas, von der Grün, Ganswindt, Belka, Peeken, Combs, Böke, Zips, Troost, Krause, Baumann, Löck (2022)
Integrated radiogenomics analyses allow for subtype classification and improved outcome prognosis of patients with locally advanced HNSCC
Sci Rep 12: 16755.
Schellhammer, Wiedkamp, Löck, Kögler (2022)
Multivariate statistical modelling to improve particle treatment verification: Implications for prompt gamma-ray timing
Front Phys 10: 932950.
Igbo, Linge, Frosch, Suckert, Stolz-Kieslich, Löck, Kumaravadivel, Welsch, Weitz, Sommer, Aust, Troost (2022)
Immunohistochemical analyses of paraffin-embedded sections after primary surgery or trimodality treatment in esophageal carcinoma
Clin Transl Radiat Oncol 36: 106-112.
Naumann, Czempiel, Lößner, Pape, Beyreuther, Löck, Drukewitz, Hennig, von Neubeck, Klink, Krause, William, Stange, Bütof, Dietrich (2022)
Combined Systemic Drug Treatment with Proton Therapy: Investigations on Patient-Derived Organoids
Cancers 14: 3781.
Bütof, Häberlein, Jentsch, Kotzerke, Lohaus, Makocki, Valentini, Weitz, Löck, Troost (2022)
Impact of Blood Parameters and Normal Tissue Dose on Treatment Outcome in Esophageal Cancer Patients Undergoing Neoadjuvant Radiochemotherapy
Cancers 14: 3504.
Riediger, Löck, Frohneberg, Hoffmann, Kahlert, Weitz (2022)
Oncological liver resection in elderly – A retrospective comparative study
Int J Surg 104: 106729.
Patil, Linge, Hiepe, Grosser, Lohaus, Gudziol, Kemper, Nowak, Haim, Tinhofer, Budach, Guberina, Stuschke, Balermpas, von der Grün, Schäfer, Grosu, Abdollahi, Debus, Ganswindt, Belka, Pigorsch, Combs, Boeke, Zips, Jöhrens, Baretton, Baumann, Krause, Löck (2022)
A Novel 2-Metagene Signature to Identify High-Risk HNSCC Patients amongst Those Who Are Clinically at Intermediate Risk and Are Treated with PORT
Cancers 14: 3031.
Shahzadi, Zwanenburg, Lattermann, Linge, Baldus, Peeken, Combs, Diefenhardt, Rödel, Kirste, Grosu, Baumann, Krause, Troost, Löck (2022)
Analysis of MRI and CT‑based radiomics features for personalized treatment in locally advanced rectal cancer and external validation of published radiomics models
Sci Rep 12: 10192.
Riediger, Hoffmann, Löck, Giehl‑Brown, Dennler, Kahlert, Weitz (2022)
Novel Personalized Score Predicts Risk for Postoperative Biliary Leak in Liver Surgery—a Retrospective Database Analysis
J Gastrointest Surg 26: 2101-2110.
Yahya, Linge, Leger, Maile, Kemper, Haim, Jöhrens, Troost, Krause, Löck (2022)
Assessment of gene expressions from squamous cell carcinoma of the head and neck to predict radiochemotherapy-related xerostomia and dysphagia
Acta Oncol 61: 856-863.
Karsch, Pawelke, Brand, Hans, Hideghéty, Jansen, Lessmann, Löck, Schürer, Schurig, Seco, Szabó, Beyreuther (2022)
Beam pulse structure and dose rate as determinants for the flash effect observed in zebrafish embryo
Radiother Oncol 173: 49-54.
Hölscher, Baumann, Kotzerke, Zöphel, Paulsen, Müller, Zips, Thomas, Wirth, Troost, Krause, Löck, Lohaus (2022)
Local Control after Locally Ablative, Image-Guided Radiotherapy of Oligometastases Identified by Gallium-68-PSMA-Positron Emission Tomography in Castration-Sensitive Prostate Cancer Patients (OLI-P)
Cancers 14: 2073.
Donix, Seidlitz, Buthut, Löck, Meissner, Matthes, Troost, Baumann, Raschke, Linn, Krause (2022)
Subjective memory impairment in glioma patients with curative radiotherapy
Radiother Oncol 171: 101-106.
Patil, Linge, Grosser, Lohaus, Gudziol, Kemper, Nowak, Haim, Tinhofer, Budach, Guberina, Stuschke, Balermpas, Rödel, Schäfer, Grosu, Abdollahi, Debus, Ganswindt, Belka, Pigorsch, Combs, Boeke, Zips, Baretton, Baumann, Krause, Löck (2022)
Development and validation of a 6-gene signature for the prognosis of loco-regional control in patients with HPV-negative locally advanced HNSCC treated by postoperative radio(chemo)therapy
Radiother Oncol 171: 91-100.
Spautz, Jakobi, Meijers, Peters, Löck, Knopf, Troost, Richter, Stützer (2022)
Experimental validation of 4D log file-based proton dose reconstruction for interplay assessment considering amplitude-sorted 4DCTs
Medical Physics 49: 3538-3549.
Schniewind, Wijaya Hadiwikarta, Grajek, Poleszczuk, Richter, Peitzsch, Müller, Klusa, Beyreuther, Löck, Lühr, Frosch, Groeben, Sommer, Krause, Dubrovska, von Neubeck, Kurth, Peitzsch (2022)
Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity
Cell Reports 38: 110422.
Müller, Leger, Zwanenburg, Suckert, Lühr, Beyreuther, Neubeck, Krause, Löck, Dietrich, Bütof (2022)
Radiomics-based tumor phenotype determination based on medical imaging and tumor microenvironment in a preclinical setting
Radiother Oncol 169: 96-104.
Löck, Linge, Lohaus, Ebert, Gudziol, Nowak, Tinhofer, Kalinauskaite, Guberina, Stuschke, Balermpas, von der Grün, Grosu, Debus, Ganswindt, Belka, Peeken, Combs, De-Colle, Zips, Baretton, Krause, Baumann (2022)
Biomarker signatures for primary radiochemotherapy of locally advanced HNSCC – hypothesis generation on a multicentre cohort of the DKTK-ROG
Radiother Oncol 169: 8-14. [Comment] [Reply]
Schwarz, Schniewind, Besso, Lange, Linge, Patil, Loeck, Klusa, Dietrich, Voss-Boehme, Nowrouzi, Krause, Dubrovska, Kurth, Peitzsch (2022)
Plasticity within aldehyde dehydrogenase-positive cells determines prostate cancer radiosensitivity
Mol Cancer Res 20: 794-809.
Overgaard, Aznar, Bacchus, Coppes, Deutsch, Georg, Haustermans, Hoskin, Krause, Lartigau, Lee, Löck, Offersen, Thwaites, van der Kogel, van der Heide, Valentini, Baumann (2022)
Personalised radiation therapy taking both the tumour and patient into consideration
Radiother Oncol 166: A1-A5.
Patil, Tawk, Grosser, Lohaus, Gudziol, Kemper, Nowak, Haim, Tinhofer, Budach, Guberina, Stuschke, Balermpas, Rödel, Schäfer, Grosu, Abdollahi, Debus, Ganswindt, Belka, Pigorsch, Combs, Boeke, Zips, Baretton, Baumann, Krause, Löck, Linge (2022)
Analyses of molecular subtypes and their association to mechanisms of radioresistance in patients with HPV-negative HNSCC treated by postoperative radiochemotherapy
Radiother Oncol 167: 300-307.
Hölscher, Baumann, Kotzerke, Zöphel, Paulsen, Müller, Zips, Koi, Thomas, Löck, Krause, Wirth, Lohaus (2022)
Toxicity and Efficacy of Local Ablative, Image-guided Radiotherapy in Gallium-68 Prostate-specific Membrane Antigen Targeted Positron Emission Tomography–staged, Castration-sensitive Oligometastatic Prostate Cancer: The OLI-P Phase 2 Clinical Trial
Eur Urol Oncol 5: 44-51.
Granzier, Ibrahim, Primakov, Keek, Halilaj, Zwanenburg, Engelen, Lobbes, Lambin, Woodruff, Smidt (2022)
Test–Retest Data for the Assessment of Breast MRI Radiomic Feature Repeatability
J Magn Reson Imaging 56: 592-604.
2021
Rassamegevanon, Feindt, Koi, Müller, Freudenberg, Löck, Sihver, Çevik, Kühn, von Neubeck, Linge, Pietzsch, Kotzerke, Baumann, Krause, Dietrich (2021)
Molecular Response to Combined Molecular- and External Radiotherapy in Head and Neck Squamous Cell Carcinoma (HNSCC)
Cancers 13: 5595.
Hoberück, Löck, Borkowetz, Sommer, Winzer, Zöphel, Fedders, Michler, Kotzerke, Kopka, Hölscher, Braune (2021)
Intraindividual comparison of [68 Ga]-Ga-PSMA-11 and [18F]-F-PSMA-1007 in prostate cancer patients: a retrospective single-center analysis
EJNMMI Res 11: 109.
Shahzadi, Lattermann, Linge, Zwanenburg, Baldus, Peeken, Combs, Baumann, Krause, Troost, Löck (2021)
Do We Need Complex Image Features to Personalize Treatment of Patients with Locally Advanced Rectal Cancer?
In: de Bruijne M. et al. (eds) Medical Image Computing and Computer Assisted Intervention – MICCAI 2021. MICCAI 2021. Lecture Notes in Computer Science, vol 12907. Springer, Cham.
Morin, Vallières, Braunstein, Barrios Ginart, Upadhaya, Woodruff, Zwanenburg, Chatterjee, Villanueva-Meyer, Valdes, Chen, Hong, Yom, Solberg, Löck, Seuntjens, Park, Lambin (2021)
An artificial intelligence framework integrating longitudinal electronic health records with real-world data enables continuous pan-cancer prognostication (open-access link)
Nature Cancer 2: 709-722 (Editorial).
Lapa, Nestle, Albert, Baues, Beer, Buck, Budach, Bütof, Combs, Derlin, Eiber, Fendler, Furth, Gani, Gkika, Grosu, Henkenberens, Ilhan, Löck, Marnitz-Schulze, Miederer, Mix, Nicolay, Niyazi, Pöttgen, Rödel, Schatka, Schwarzenboeck, Todica, Weber, Wegen, Wiegel, Zamboglou, Zips, Zöphel, Zschaeck, Thorwarth, Troost (2021)
Value of PET imaging for radiation therapy
Strahlenther Onkol 197: 1-23, Nuklearmedizin 60: 326-343.
Nathansen, Lukiyanchuk, Hein, Stolte, Borgmann, Löck, Ina, Baumann, Krause, Linge, Dubrovska (2021)
Oct4 confers stemness and radioresistance to head and neck squamous cell carcinoma by regulating the homologous recombination factors PSMC3IP and RAD54L
Oncogene 40: 4214-4228.
Mukha, Kahya, Linge, Chen, Löck, Lukiyanchuk, Richter, Alves, Peitzsch, Telychko, Skvortsov, Negro, Aschenbrenner, Skvortsova, Mirtschink, Lohaus, Hölscher, Neubauer, Rivandi, Labitzky, Lange, Franken, Behrens, Stoecklein, Toma, Sommer, Zschaeck, Rehm, Eisenhofer, Schwager, Abdollahi, Groeben, Kunz-Schughart, Baretton, Baumann, Krause, Peitzsch, Dubrovska (2021)
GLS-driven glutamine catabolism contributes toprostate cancer radiosensitivity by regulating the redoxstate, stemness and ATG5-mediated autophagy
Theranostics 11: 7844-7868.
Dutz, Lühr, Troost, Agolli, Bütof, Valentini, Baumann, Vermeren, Geismar, Timmermann, Krause, Löck (2021)
Identification of patient benefit from proton beam therapy in brain tumour patients based on dosimetric and NTCP analyses
Radiother Oncol 160: 69-77.
Lutz, Eulitz, Haneke-Swanson, Enghardt, Lühr (2021)
Precision modeling of the IBA Universal Nozzle double scattering mode at the University Proton Therapy Dresden for Monte Carlo simulation
JINST 16: T03007l.
Ciecior, Ebert, Borgeaud, Thames, Baumann, Krause, Löck (2021)
Sample-size calculation for preclinical dose-response experiments using heterogeneous tumour models
Radiother Oncol 158: 262-267.
Kummer, Löck, Gurtner, Hermann, Yaromina, Eicheler, Baumann, Krause, Jentsch (2021)
Value of functional in-vivo endpoints in preclinical radiation research
Radiother Oncol 158: 155-161.
Pawelke, Brand, Hans, Hideghéty, Karsch, Lessmann, Löck, Schürer, Szabó, Beyreuther (2021)
Electron dose rate and oxygen depletion protect zebrafish embryos from radiation damage
Radiother Oncol 158: 7-12.
Dutz, Lühr, Agolli, Bütof, Valentini, Troost, Baumann, Vermeren, Geismar, Lamba, Lebow, Bussière, Daly, Bussière, Krause, Timmermann, Shih, Löck (2021)
Modelling of late side-effects following cranial proton beam therapy
Radiother Oncol 157: 15-23.
Seidlitz, Beuthien-Baumann, Löck, Jentsch, Platzek, Zöphel, Linge, Kotzerke, Petr, van den Hoff, Steinbach, Krex, Schmitz-Schackert, Falk, Baumann, Krause (2021)
Final results of the prospective biomarker trial PETra: [11C]-MET-accumulation in postoperative PET/MRI predicts outcome after radiochemotherapy in glioblastoma
Clin Cancer Res 7: 1351-60.
Aznar, Bacchus, Coppes, Deutsch, Georg, Haustermans, Hoskin, Krause, Lartigau, Löck, Offersen, Overgaard, Thwaites, van der Kogel, van der Heide, Valentini, Baumann (2021)
Radiation oncology in the new virtual and digital era
Radiother Oncol 154: A1-A4.
Dietrich, Andreeff, Koi, Bergmann, Schubert, Schreiner, Löck, Sihver, Freudenberg, Hering, Pietzschg, Steinbach, Kotzerke, Baumann, Krause (2021)
Radiotherapy enhances uptake and efficacy of 90Y-cetuximab: A preclinical trial
Radiother Oncol 155: 285-292.
Zschaeck, Zöphel, Seidlitz, Zips, Kotzerke, Baumann, Troost, Löck, Krause (2021)
Generation of biological hypotheses by functional imaging links tumor hypoxia to radiation induced tissue inflammation/glucose uptake in head and neck cancer
Radiother Oncol 155: 204-211.
Rabasco-Meneghetti, Zwanenburg, Leger, Leger, Troost, Lohaus, Linge, Schreiber, Kalinauskaite, Tinhofer, Guberina, Guberina, Balermpas, von der Grün, Ganswindt, Belka, Peeken, Combs, Boeke, Zips, Krause, Baumann, Löck (2021)
Definition and validation of a radiomics signature for loco-regional tumour control in patients with locally advanced head and neck squamous cell carcinoma
Clin Transl Radiat Oncol 26: 62-70.
Ebert, Kensche, Löck, Hadiwikarta, Hänsch, Dörr, Krause, Hannig, Baumann (2021)
Results of a randomized controlled phase III trial: efficacy of polyphenol-containing cystus® tea mouthwash solution for the reduction of mucositis in head and neck cancer patients undergoing external beam radiotherapy
Strahlenther Onkol 197: 63-73.
Chen, Manig, Lehmann, Sorour, Löck, Yu, Dubrovska, Baumann, Kessler, Stasyk, Kunz-Schughart (2021)
Dual role of ER stress in response to metabolic co-targeting and radiosensitivity in head and neck cancer cells
Cell Mol Life Sci 78: 3021-3044.
2020
Rabasco Meneghetti, Zwanenburg, Löck (2020)
Pictures worth more than a thousand words: Prediction of survival in medulloblastoma patients
EBioMedicine 62: 1003136.
Leger, Zwanenburg, Leger, Lohaus, Linge, Schreiber, Kalinauskaite, Tinhofer, Guberina, Guberina, Balermpas, von der Grün, Ganswindt, Belka, Peeken, Combs, Boeke, Zips, Richter, Krause, Baumann, Troost, Löck (2020)
Comprehensive Analysis of Tumour Sub-Volumes for Radiomic Risk Modelling in Locally Advanced HNSCC
Cancers 12: 3047.
Starke, Leger, Zwanenburg, Leger, Lohaus, Linge, Schreiber, Kalinauskaite, Tinhofer, Guberina, Guberina, Balermpas, von der Grün, Ganswindt, Belka, Peeken, Combs, Boeke, Zips, Richter, Troost, Krause, Baumann, Löck (2020)
2D and 3D convolutional neural networks for outcome modelling of locally advanced head and neck squamous cell carcinoma.
Scientific Reports 10: 15625.
Hoberück, Löck, Winzer, Zöphel, Froehner, Fedders, Kotzerke, Hölscher (2020)
[68Ga]Ga-PSMA-11 PET before and after initial long-term androgen deprivation in patients with newly diagnosed prostate cancer: a retrospective single-center study
Eur J Nucl Med Mol Imaging 10: 135.
Raschke, Seidlitz, Wesemann, Löck, Jentsch, Platzek, Petr, van den Hoff, Kotzerke, Beuthien-Baumann, Baumann, Linn, Krause, Troost (2020)
Dose dependent cerebellar atrophy in glioma patients after radio(chemo)therapy
Radiother Oncol 150: 262-267.
Socarrás Fernández, Mönnich, Leibfarth, Welz, Zwanenburg, Leger, Löck, Pfannenberg, La Fougère Reischl, Baumann, Zips, Thorwarth (2020)
Comparison of patient stratification by computed tomography radiomics and hypoxia positron emission tomography in head-and-neck cancer radiotherapy
Phys Imag Radiat Oncol 15: 52-59.
Dinger, Chen, Dittfeld, Hetze, Hüther, Wondrak, Löck, Eicheler, Breier, Kunz-Schughart (2020)
Microenvironmentally-driven Plasticity of CD44 isoform expression determines Engraftment and Stem-like Phenotype in CRC cell lines
Theranostics 10: 7599-7621.
Suckert, Rassamegevanon, Müller, Dietrich, Graja, Reiche, Löck, Krause, Beyreuther, von Neubeck (2020)
Applying Tissue Slice Culture in Cancer Research—Insights from Preclinical Proton Radiotherapy
Cancers 12: 1589.
Depeursinge, Andrearczyk, Whybra, van Griethuysen, Müller, Schaer, Vallières, Zwanenburg (for the Image Biomarker Standardisation Initiative) [2020]
Standardised convolutional filtering for radiomics
arXiv:2006.05470 [cs.CV].
Zschaeck, Löck, Hofheinz, Zips, Mortensen, Zöphel, Troost, Boeke, Saksø, Mönnich, Seidlitz, Johansen, Skripcak, Gregoire, Overgaard, Baumann, Krause (2020)
Individual patient data meta-analysis of FMISO and FAZA hypoxia PET scans from head and neck cancer patients undergoing definitive radio-chemotherapy
Radiother Oncol 149: 189-196.
Zwanenburg, Vallières, Abdalah, Aerts, Andrearczyk, Apte, Ashrafinia, Bakas, Beukinga, Boellaard, Bogowicz, Boldrini, Buvat, Cook, Davatzikos, Depeursinge, Desseroit, Dinapoli, Dinh, Echegaray, El Naqa, Fedorov, Gatta, Gillies, Goh, Götz, Guckenberger, Ha, Hatt, Isensee, Lambin, Leger, Leijenaar, Lenkowicz, Lippert, Losnegård, Maier-Hein, Morin, Müller, Napel, Nioche, Orlhac, Pati, Pfaehler, Rahmim, Rao, Scherer, Siddique, Sijtsema, Socarras Fernandez, Spezi, Steenbakkers, Tanadini-Lang, Thorwarth, Troost, Upadhaya, Valentini, van Dijk, van Griethuysen, van Velden, Whybra, Richter, Löck (2020)
The image biomarker standardization initiative: standardized quantitative radiomics for high-throughput image-based phenotyping
Radiology 295: 328-338.
Schmidt, Linge, Großer, Lohaus, Gudziol, Nowak, Tinhofer, Budach, Sak, Stuschke, Balermpas, Rödel, Schäfer, Grosu, Abdollahi, Debus, Ganswindt, Belka, Pigorsch, Combs, Mönnich, Zips, Baretton, Buchholz, Baumann, Krause, Löck (2020)
Comparison of GeneChip, nCounter, and Real-Time PCR-Based Gene Expressions Predicting Locoregional Tumor Control after Primary and Postoperative Radiochemotherapy in Head and Neck Squamous Cell Carcinoma
J Mol Diagn 22: 801-810.
Meneceur, Linge, Meinhardt, Hering, Löck, Bütof, Krex, Schackert, Temme, Baumann, Krause, von Neubeck (2020)
Establishment and Characterisation of Heterotopic Patient-Derived Xenografts for Glioblastoma
Cancers 12: 871.
Krause, Alsner, Linge, Bütof, Löck, Bristow (2020)
Specific requirements for translation of biological research into clinical radiation oncology
Mol Oncol 14: 1569-1576.
Troost, Wink, Roelofs, Simone, Makocki, Löck, van Kollenburg, Dechambre, Minken, van der Stoep, Avery, Jansen, Solberg, Bussink, de Ruysscher (2020)
Photons or protons for reirradiation in (non-)small cell lung cancer: Results of the multicentric ROCOCO in silico study
Br J Radiol 93: 20190879.
Dutz, Agolli, Bütof, Valentini, Baumann, Lühr, Löck, Krause (2020)
Neurocognitive function and quality of life after proton beam therapy for brain tumour patients
Radiother Oncol 143: 108-116.
Bütof, Löck, Soliman, Haase, Perrin, Richter, Appold, Krause, Baumann (2020)
Dose–volume predictors of early esophageal toxicity in non-small cell lung cancer patients treated with accelerated-hyperfractionated radiotherapy
Radiother Oncol 143: 44-50.
Stölzel, Lüer, Löck, Parmentier, Kuithan, Kramer, Alakel, Sockel, Taube, Middeke, Schetelig, Röllig, Paulus, Kotzerke, Ehninger, Bornhäuser, Schaich, Zoephel (2020)
The prevalence of extramedullary acute myeloid leukemia detected by 18FDG-PET/CT: final results from the Prospective PETAML Trial
Haematologica 105: 1552-1558.
2019
Starke S, Eckert C, Zwanenburg A, Speidel S, Löck S, Leger S (2019)
An Integrative Analysis of Image Segmentation and Survival of Brain Tumour Patients
In: Crimi A., Bakas S. (eds) Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries. BrainLes 2019. Lecture Notes in Computer Science, vol 11992. Springer, Cham
Karsch L, Beyreuther E, Passos DE, Pawelke J, Löck S (2019)
Analysing Tumour Growth Delay Data from Animal Irradiation Experiments with Deviations from the Prescribed Dose
Cancers 11: 1281.
Rassamegevanon T, Löck S, Baumann M, Krause M, von Neubeck C (2019)
Comparable radiation response of ex vivo and in vivo irradiated tumor samples determined by residual γH2AX
Radiother Oncol 139: 94-100.
Hoberück S, Michler E, Wunderlich G, Löck S, Hölscher T, Froehner M, Braune A, Platzek I, Seppelt D, Zöphel K, Kotzerke J (2019)
68Ga-RM2 PET in PSMA- positive and -negative prostate cancer patients
Nuklearmedizin 58: 352-362.
Eulitz J, Troost EGC, Raschke F, Schulz E, Lutz B, Dutz A, Löck S, Wohlfahrt P, Enghardt W, Karpowitz C, Krause M, Lühr A (2019)
Predicting late magnetic resonance image changes in glioma patients after proton therapy
Acta Oncologica 58: 10.
Zwanenburg A (2019)
Radiomics in nuclear medicine: robustness, reproducibility, standardization, and how to avoid data analysis traps and replication crisis
Eur J Nucl Med Mol Imaging 46: 2638–2655.
Meneceur S, Löck S, Gudziol V, Hering S, Bütof R, Rehm M, Baumann M, Krause M, von Neubeck C (2019)
Residual gammaH2AX foci in head and neck squamous cell carcinomas as predictors for tumour radiosensitivity: Evaluation in pre-clinical xenograft models and clinical specimens
Radiother Oncol 137: 24-31
[Corrigendum Radiother Oncol 183: 109619].
Richter C, Andronesi OC, Borra RJH, Voigt F, Löck S, Dudaa DG, Guimaraes AR, Hong TS, Bortfeld TR, Seco J (2019)
Inter-patient variations of radiation-induced normal-tissue changes in Gd-EOB-DTPA-enhanced hepatic MRI scans during fractionated proton therapy
Clin Transl Radiat Oncol 18: 113-119.
Kohler A, Löck S, Appold S, Bandurska-Luque A, Hoberück S, Schreiber A, Kotzerke J, Zips D, Zöphel K (2019)
Comparison of subjective evaluation versus objective algorithm in the interpretation of follow-up FDG-PET/CT scans after radiochemotherapy in head and neck cancer patients
Nuklearmedizin 58: 93-100.
Dutz A, Agolli L, Baumann M, Troost EGC, Krause M, Hölscher T, Löck S (2019)
Early and late side effects, dosimetric parameters and quality of life after proton beam therapy and IMRT for prostate cancer: a matched-pair analysis
Acto Onologica 58: 916-925.
Correction, Acta Oncologica, 59: 608-609 (2020).
Linge A, Schmidt S, Lohaus F, Krenn C, Bandurska-Luque A, Platzek I, von Neubeck C, Appold S, Nowak A, Gudziol V, Buchholz F, Baretton GB, Baumann M, Löck S, Krause M (2019)
Independent validation of tumour volume, cancer stem cell markers and hypoxia-associated gene expressions for HNSCC after primary radiochemotherapy
Clin Transl Radiat Oncol 16: 40-47.
Löck S, Linge A, Seidlitz A, Bandurska-Luque A, Nowak A, Gudziol V, Buchholz F, Aust DE, Baretton GB, Zöphel K, Steinbach J, Kotzerke J, Overgaard J, Zips D, Krause M, Baumann M, Troost EGC (2019)
Repeat FMISO-PET imaging weakly correlates with hypoxia-associated gene expressions for locally advanced HNSCC treated by primary radiochemotherapy
Radiother Oncol 135: 43-50.
Pfaehler E, Zwanenburg A, de Jong JR, Boellaard R (2019)
RaCaT: An open source and easy to use radiomics calculator tool
PLoS ONE 14: e0212223.
Bandurska-Luque A, Löck S, Haase R, Richter C, Zöphel K, Perrin R, Appold S, Krause M, Steinbach J, Kotzerke J, Hofheinz F, Zips D, Baumann M, Troost EGC (2019)
Correlation between FMISO-PET based hypoxia in the primary tumour and in lymph node metastases in locally advanced HNSCC patients
Clin Transl Radiat Oncol 15: 108-112.
Rauschenberg R, Bruns J, Brütting J, Daubnerd D, Lohaus F, Zimmer L, Forschner A, Zips D, Hassel JC, Berking C, Kaehler KC, Utikal J, Gutzmer R, Terheyden P, Meiss F, Rafei-Shamsabadi D, Kiecker F, Debus D, Dabrowski E, Arnold A, Garzarolli M, Kuske M, Beissert S, Löck S, Linn J, Troost EGC, Meier F (2019)
Impact of radiation, systemic therapy and treatment sequencing on survival of patients with melanoma brain metastases
Eur J Cancer 110: 11-20.
Zwanenburg A, Leger S, Agolli L, Pilz K, Troost EGC, Richter C, Löck S (2019)
Assessing robustness of radiomic features by image perturbation
Scientific Reports 9: 614.
Digomann D, Kurth I, Tyutyunnykova A, Chen O, Löck S, Gorodetska I, Peitzsch C, Skvortsova I, Negro G, Aschenbrenner B, Eisenhofer G, Richter S, Heiden S, Porrmann J, Klink B, Schwager C, Dowle AA, Hein L, Kunz-Schughart LA, Abdollahi A, Lohaus F, Krause M, Baumann M, Linge A, Dubrovska A (2019)
The CD98 heavy chain is a marker and regulator of head and neck squamous cell carcinoma radiosensitivity
Clin Cancer Res 25: 3152-3163.
Wink K, Löck S, Rossi M, Baardwijk A, Belderbos J, Ruysscher D, Troost E (2019)
Contact of a tumour with the pleura is not associated with regional recurrence following stereotactic ablative radiotherapy for early stage non-small cell lung cancer
Radiother Oncol 131: 120-126.
Dutz A, Löck S (2019)
Competing risks in survival data analysis
Radiother Oncol 130: 185-189.
Bandurska-Luque A, Löck S, Haase R, Richter C, Zöphel K, Abolmaali N, Seidlitz A, Appold S, Krause M, Steinbach J, Kotzerke J, Zips D, Baumann M, Troost EGC (2019)
FMISO-PET-based lymph node hypoxia adds to the prognostic value of tumor only hypoxia in HNSCC patients
Radiother Oncol 130: 97-103.
Leger S, Zwanenburg A, Pilz K, Zschaeck S, Zöphel K, Kotzerke J, Schreiber A, Zips D, Krause M, Baumann M, Troost EGC, Richter C, Löck S (2019)
CT imaging during treatment improves radiomic models for patients with locally advanced head and neck cancer
Radiother Oncol 130: 10-17.
Dutz A, Lühr A, Agolli L, Troost EGC, Krause M, Baumann M, Vermeren X, Geismar D, Schapira EF, Bussière M, Daly JE, Bussière MR, Timmermann B, Shih HA, Löck S (2019)
Development and validation of NTCP models for acute side-effects resulting from proton beam therapy of brain tumours
Radiother Oncol 130: 164-171.
Lohaus F, Zöphel K, Löck S, Wirth M, Kotzerke J, Krause M, Baumann M, Troost E, Hölscher T (2019)
Can Local Ablative Radiotherapy Revert Castration-resistant Prostate Cancer to an Earlier Stage of Disease?
Eur Urol 75: 548-551.
Aktar R, Dietrich A, Tillner F, Kotb S, Löck S, Willers H, Baumann M, Krause M, Bütof R (2019)
Pre-clinical imaging for establishment and comparison of orthotopic non-small cell lung carcinoma: in search for models reflecting clinical scenarios
Br J Radiol 92: 20180539.
2018
Cordes N, Ney M, Beleites T, Aust D, Baretton G, Thames H, Baumann M, Krause M, Löck S, Appold S (2018)
Retrospective investigation of the prognostic value of the β1 integrin expression in patients with head and neck squamous cell carcinoma receiving primary radio(chemo)therapy
PLoS ONE 13: e0209479.
Rassamegevanon T, Löck S, Baumann M, Krause M, von Neubeck C (2018)
Heterogeneity of γH2AX Foci Increases in Ex Vivo Biopsies Relative to In Vivo Tumors.
Int J Mol Sci 19: 2616.
Dutz A, Troost EGC, Löck S (2018)
Keine Überlegenheit der Protonentherapie gegenüber der IMRT beim lokal fortgeschrittenen NSCLC
Strahlenther Onkol 194: 790-793.
Dutz A, Troost EGC, Löck S (2018)
Keine Überlegenheit gegenüber der IMRT
InFo Onkologie 21: 22-24.
Zwanenburg A, Löck S (2018)
Why validation of prognostic models matters?
Radiother Oncol 127: 370-373.
Schmidt S, Linge A, Zwanenburg A, Leger S, Lohaus F, Krenn C, Appold S, Gudziol V, Nowak A, von Neubeck C, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Bunea H, Grosu AL, Abdollahi A, Debus J, Ganswindt U, Belka C, Pigorsch SU, Combs SE, Mönnich D, Zips D, Baretton GB, Buchholz F, Baumann M, Krause M, Löck S (2018)
Development and validation of a gene signature for patients with head and neck squamous cell carcinomas treated by postoperative radio(chemo)therapy
Clin Cancer Res 24: 1367-1374.
Linge A, Schötz U, Löck S, Lohaus F, von Neubeck C, Gudziol V, Nowak A, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Bunea H, Grosu AL, Abdollahi A, Debus J, Ganswindt U, Lauber K, Pigorsch A, Combs SE, Mönnich D, Zips D, Baretton GB, Buchholz F, Krause M, Belka C, Baumann M (2018)
Comparison of detection methods for HPV status as a prognostic marker for loco-regional control after radiochemotherapy in patients with HNSCC
Radiother Oncol 127: 27-35.
Vallières M, Zwanenburg A, Badic B, Cheze‐Le Rest C, Visvikis D, Hatt M (2018)
Responsible Radiomics Research for Faster Clinical Translation
J Nucl Med 59: 189-193.
Hinrichs CN, Ingargiola M, Käubler T, Löck S, Temme A, Köhn-Luque A, Deutsch A, Vovk O, Stasyk O, Kunz-Schughart LA (2018)
Arginine Deprivation Therapy: Putative Strategy to Eradicate Glioblastoma Cells by Radiosensitization
Mol Cancer Ther 17: 393-406.
2017
Bütof R, Simon M, Löck S, Troost EGC, Appold S, Krause M, Baumann M (2017)
PORTAF–postoperative radiotherapy of non-small cell lung cancer: accelerated versus conventional fractionation–study protocol for a randomized controlled trial
Trials 18: 608.
Leger S, Löck S, Hietschold V, Haase R, Böhme HJ, Abolmaali N (2017)
Physical correction model for automatic correction of intensity non-uniformity in magnetic resonance imaging
Phys Imag Rad Oncol 4: 32-38.
Cubillos-Mesías M, Bauman M, Troost EGC, Löck S, Richter C, Stützer K (2017)
Impact of robust treatment planning on single- and multi-field optimized plans for proton beam therapy of unilateral head and neck target volumes
Radiation Oncology 12: 190.
Bütof R, Gumina C, Valentinia C, Sommerer A, Appold S, Zips D, Löck S, Baumann M, Troost EGC (2017)
Sites of recurrent disease and prognostic factors in SCLC patients treated with radiochemotherapy
Clin Transl Radiat Oncol 7: 36-42.
Leger S, Zwanenburg A, Pilz K, Lohaus F, Linge A, Zöphel K, Kotzerke J, Schreiber A, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Ganswindt U, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips D, Krause M, Baumann M, Troost EGC, Löck S, Richter C (2017)
A comparative study of machine learning methods for time-to-event survival data for radiomics risk modelling
Scientific Reports 7: 13206.
Stützer K, Jakobi A, Bandurska-Luque A, Barczyk S, Arnsmeyer C, Löck S, Richter C (2017)
Potential proton and photon dose degradation in advanced head and neck cancer patients by intratherapy changes
J Appl Clin Med Phys 18: 104-113.
Löck S, Perrin R, Seidlitz A, Bandurska-Luque A, Zschaeck S, Zöphel K, Krause M, Steinbach J, Kotzerke J, Zips D, Troost EGC, Baumann M (2017)
Residual tumour hypoxia in head-and-neck cancer patients undergoing primary radiochemotherapy, final results of a prospective trial on repeat FMISO-PET imaging
Radiother Oncol 124: 533-540.
Koi L, Löck S, Linge A, Thurow C, Hering S, Baumann M, Krause M, Gurtner K (2017)
EGFR-amplification plus gene expression profiling predicts response to combined radiotherapy with EGFR-inhibition: A preclinical trial in 10 HNSCC-tumour-xenograft models
Radiother Oncol 124: 496-503.
Lühr A, Löck S, Jakobi A, Stützer K, Bandurska-Luque A, Vogelius IR, Enghardt W, Baumann M, Krause M (2017)
Modeling tumor control probability for spatially inhomogeneous risk of failure based on clinical outcome data
Z Med Phys 27: 285-299.
Rassamegevanon T, Löck S, Range U, Krause M, Baumann M, von Neubeck C (2017)
Tumor heterogeneity determined with a γH2AX foci assay: A study in human head and neck squamous cell carcinoma (hHNSCC) models
Radiother Oncol 124: 379-385.
Zschaeck S, Hofheinz F, Zöphel K, Bütof R, Jentsch C, Schmollack J, Löck S, Kotzerke J, Baretton G, Weitz J, Baumann M, Krause M (2017)
Increased FDG uptake on late-treatment PET in non-tumour-affected oesophagus is prognostic for pathological complete response and disease recurrence in patients undergoing neoadjuvant radiochemotherapy
Eur J Nucl Med Mol Imaging 44: 1813-1822.
Zschaeck S, Löck S, Leger S, Haase, R Bandurska-Luque A, Appold S, Kotzerke J, Zips D, Richter C, Gudziol V, Schreiber A, Zöphel K, Baumann M, Krause M (2017)
FDG uptake in normal tissues assessed by PET during treatment has prognostic value for treatment results in head and neck squamous cell carcinomas undergoing radiochemotherapy
Radiother Oncol 122: 437-444.
Tomkovič J, Muessel W, Strobel H, Löck S, Schlagheck P, Ketzmerick R, Oberthaler MK (2017)
Experimental observation of the Poincaré-Birkhoff scenario in a driven many-body quantum system
Phys Rev A 95: 011602(R).
Liebscher S, Koi L, Löck S, Muders MH, Krause M (2017)
The HIV protease and PI3K/Akt inhibitor nelfinavir does not improve the curative effect of fractionated irradiation in PC-3 prostate cancer in vitro and in vivo
Clin Transl Radiat Oncol 2: 7-12.
2016
Linge A, Löck S, Krenn C, Appold S, Lohaus F, Nowak A, Gudziol V, Baretton GB, Buchholz F, Baumann M, Krause M (2016)
Independent validation of the prognostic value of cancer stem cell marker expression and hypoxia-induced gene expression for patients with locally advanced HNSCC after postoperative radiotherapy
Clin Transl Radiat Oncol 1: 19-26.
Zwanenburg A, Leger A, Vallières M, Löck S (2016)
Image biomarker standardisation initiative - feature definitions
arXiv:1612.07003 [cs.CV].
Linge A, Lohaus F, Löck S, Nowak A, Gudziol V, Valentini C, von Neubeck C, Jütz M, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Grosu AL, Abdollahi A, Debus J, Ganswindt U, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips D, Buchholz F, Aust DE, Baretton GB, Thames HD, Dubrovska A, Alsner J, Overgaard J, Krause M, Baumann M (2016)
HPV status, cancer stem cell marker expression, hypoxia gene signatures and tumour volume identify good prognosis subgroups in patients with HNSCC after primary radiochemotherapy: A multicentre retrospective study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)
Radiother Oncol 121: 364-373.
Zschaeck S, Simon M, Löck S, Troost ET, Stützer K, Wohlfahrt P, Appold S, Makocki S, Bütof R, Richter C, Baumann M, Krause M (2016)
PRONTOX – proton therapy to reduce acute normal tissue toxicity in locally
advanced non-small-cell lung carcinomas (NSCLC): study protocol for a randomised controlled trial
Trials 17: 543.
Kurlishchuk Y, Vynnytska-Myronovska B, Grosse-Gehling P, Bobak Y, Manig F, Chen O, Merker SR, Henle T, Löck S, Stange DE, Stasyk O, Kunz-Schughart LA (2016)
Co-application of canavanine and irradiation uncouples anticancer potential of arginine deprivation from citrulline availability
Oncotarget 7: 73292-73308.
Jentsch C, Bergmann R, Brüchner K, Mosch B, Yaromina A, Krause M, Zips D, Troost EG, Löck S, Kotzerke J, Steinbach J, Thames H, Baumann M, Beuthien-Baumann B (2016)
Impact of pre- and early per-treatment FDG-PET based dose-escalation on local tumour control in fractionated irradiated FaDu xenograft tumours
Radiother Onco 121: 447-452.
Stützer K, Haase R, Lohaus F, Barczyk S, Exner F, Löck S, Rühaak J, Lassen-Schmidt B, Corr D and Richter C (2016)
Evaluation of a deformable registration algorithm for subsequent lung computed tomography imaging during radiochemotherapy
Med Phys 43: 5028-5039.
Linge A, Lohaus F, Löck S, Krause M, Baumann M (2016)
Biomarker für die individualisierte Strahlentherapie
Nova Acta Leopoldina NF 121: 333-344.
Tillner F, Thute P, Löck S, Dietrich A, Fursov A, Haase R, Lukas M, Rimarzig B, Sobiella M, Krause M, Baumann M, Bütof R, Enghardt W (2016)
Precise image-guided irradiation of small animals: a flexible non-profit platform
Phys Med Biol 61: 3084.
Linge A, Löck S, Gudziol V, Nowak A, Lohaus F, von Neubeck C, Jütz M, Abdollahi A, Debus J, Tinhofer I, Budach V, Sak A, Stuschke M, Balermpas P, Rödel C, Avlar M, Grosu AL, Bayer C, Belka C, Pigorsch S, Combs SE, Welz S, Zips D, Buchholz F, Aust DE, Baretton GB, Thames H, Dubrovska A, Alsner J, Overgaard J, Baumann M, Krause M (2016)
Low CSC marker expression and low hypoxia identify good prognosis subgroups in HPV(-)HNSCC after postoperative radiochemotherapy: a multicenter study of the DKTK-ROG
Clin Cancer Res 22: 2639-49
2015
Jakobi A, Lühr A, Stützer K, Bandurska-Luque A, Löck S, Krause M, Baumann M, Perrin R, Richter C (2015)
Increase in Tumor Control and Normal Tissue Complication Probabilities in Advanced Head-and-Neck Cancer for Dose-Escalated Intensity-Modulated Photon and Proton Therapy
Front Oncol 5: 256.
Jakobi A, Stützer K, Bandurska-Luque A, Löck S, Haase R, Wack LJ, Mönnich D, Thorwarth D, Perez D, Lühr A, Zips D, Krause M, Baumann M, Perrin R, Richter C (2015)
NTCP reduction for advanced head and neck cancer patients using proton therapy for complete or sequential boost treatment versus photon therapy
Acta Oncol 54: 1558-1664.
Gehler S, Löck S, Shinohara S, Bäcker A, Ketzmerick R, Kuhl U, Stöckmann HJ (2015)
Experimental Observation of Resonance-Assisted Tunneling
Phys Rev Lett 115: 104101.
Seidlitz A, Siepmann T, Löck S, Juratli T, Baumann M, Krause M (2015)
Impact of waiting time after surgery and overall time of postoperative radiochemotherapy on treatment outcome in glioblastoma multiforme
Radiat Oncol 10: 172.
Bütof R, Hofheinz F, Zöphel K, Stadelmann T, Schmollack J, Jentsch C, Löck S, Kotzerke J, Baumann M, van den Hoff J (2015)
Prognostic value of pretherapeutic tumor-to-blood standard uptake ratio (SUR) in patients with esophageal carcinoma
J Nucl Med 56: 1150-1156.
Jakobi A, Bandurska-Luque A, Stützer K, Haase R, Löck S, Wack LJ, Mönnich D, Thorwarth D, Perez D, Lühr A, Zips D, Krause M, Baumann M, Perrin R, Richter C (2015)
Identification of patient benefit from proton therapy for advanced head and neck cancer patients based on individual and subgroup NTCP analysis
Int J Radiat Oncol Biol Phys 92: 1165–1174.
Löck S, Roth K, Skripcak T, Worbs M, Helmbrecht S, Jakobi A, Just U, Krause M, Baumann M, Enghardt W, Lühr A (2015)
Implementation of a software for REmote COMparison of PARticlE and photon treatment plans: ReCompare
Z Med Phys 25: 287-294.
2014
Lohaus F, Linge A, Tinhofer I, Budach V, Gkika E, Stuschke M, Balermpas P, Rödel C, Avlar M, Grosu A, Abdollahi A, Debus J, Bayer C, Belka C, Pigorsch S, Combs SE, Mönnich D, Zips D, von Neubeck C, Baretton GB, Löck S, Thames HD, Krause M, Baumann M (2014)
HPV16 DNA status is a strong prognosticator of loco-regional control after postoperative radiochemotherapy of locally advanced oropharyngeal carcinoma:Results from a multicentre explorative study of the German Cancer Consortium Radiation Oncology Group (DKTK-ROG)
Radiother Oncol 113: 317.
Lühr A, Löck S, Roth K, Helmbrecht S, Jakobi A, Petersen JB, Just U, Krause M, Enghardt W, Baumann M (2014)
Concept for individualized patient allocation: ReCompare-remote comparison of particle and photon treatment plans
Radiat Oncol 9: 59.
Bütof R, Kirchner K, Appold S, Löck S, Rolle A, Höffken G, Krause M, Baumann M (2014)
Potential clinical predictors of outcome after postoperative radiotherapy of non-small cell lung cancer
Strahlenther Onkol 190: 263–269.