| Trial population | Inclusion Criteria: - Phase Ia part: advanced solid tumors or metastases including lymphoma localized in the head and neck region or thorax with an indication for fractionated palliative RT (Arm A)
- Phase Ib part: treatment-naïve Stage III A/B NSCLC not eligible for surgical resection or concurrent chemoradiation (Arm A expansion cohort)
- cPoP study: any tumor with at least 2 (sub)cutaneous tumor/metastases at least 2 cm apart which are RT naïve with an indication for high dose palliative RT
- Availability of archival tumor material, either as a block or slides (Phase Ia and Ib). If no archival material is available then a fresh biopsy should be taken
- Willing to have tumor biopsies collected in cPoP
- Measurable or evaluable disease by RECIST v1.1 (not required for the cPoP study)
- Eastern Cooperative Oncology Group performance status (ECOG PS) ≤2
- Life expectancy of ≥3 months (Phase Ia Arm A) or ≥6 months (Phase Ib).
- Female subjects of childbearing potential and male subjects with female partners of childbearing potential must be willing to avoid pregnancy.
Exclusion Criteria: Main exclusion criteria for Phase Ia and Phase Ib: - Chemotherapy, immunotherapy, hormonal therapy, biologic therapy, or any other anticancer therapy or IMP within 28 days of first trial drug intake for Phase Ia subjects, andany prior therapy for Phase Ib subjects. For subjects with rapidly growing tumors localizedin the head and neck region or thorax where the treating physician cannot wait for 28 days,inclusion may take place if there is no residual toxicity from previous treatment (maximumCTCAE Grade 1)
- Prior RT to the same region within 12 months (Phase Ia, Arm A; subjects with tumors localized in the head and neck region or thorax) or at any time previously (Phase Ib; treatment-naïve subjects with Stage III A/B NSCLC)
- Extensive prior RT on ≥30% of bone marrow reserve as judged by the investigator or priorbone marrow/stem cell transplantation within 5 years before trial start.
- Poor vital organ functions defined as:
- Bone marrow impairment as evidenced by hemoglobin <10.0 g/dL, neutrophilcount <1.0 × 109/L, platelets <100 × 109/L
- Renal impairment as evidenced by serum creatinine >1.5 × upper limit of normal (ULN)
- Liver function abnormality as defined by total bilirubin >1.5 × ULN or aspartateaminotransferase (AST)/alanine aminotransferase (ALT) >2.5 × ULN (except for subjects with liver involvement, who can have AST/ALT >5 × ULN)
- Abnormality in coagulation parameters. Received oral or parenteral anticoagulants or thrombolytic agents within 10 days of the first dose of trial drug. Low dose highmolecular weight heparin is permitted if international normalized ratio is within the
normal range - History of difficulty swallowing, malabsorption or other chronic gastrointestinal disease or conditions that may hamper compliance and/or absorption of the IMP, use of percutaneous
endoscopic gastrostomy (PEG) tubes - Significant cardiac conduction abnormalities, including a history of long QTc syndrome and/or pacemaker, or impaired cardiovascular function such as New York Heart Association
classification score >2. - Subjects currently receiving (or unable to stop using prior to receiving the first dose of trial drug) medications or herbal supplements known to be potent inhibitors of cytochrome P450
(CYP)3A or CYP2C19 (must stop at least 1 week prior), potent inducers of CYP3A or CYP2C19 (must stop at least 3 weeks prior), or drugs mainly metabolized by CYP3A with a narrow therapeutic index (must stop at least one day prior). - Subjects currently receiving H2-blocker or proton pump inhibitors (or unable to stop at least 5 days prior to the first treatment).
Main exclusion criteria for cPoP- History of difficulty swallowing, malabsorption or other chronic gastrointestinal disease or conditions that may hamper compliance and/or absorption of the IMP
- History of any other significant medical disease such as major gastric or small bowel surgery, recent drainage of significant volumes of ascites or pleural effusion (as per Investigator’s judgement) or a psychiatric condition that might impair the subject’s wellbeing or preclude full participation in the trial
- Subjects currently receiving (or unable to stop using prior to receiving the first dose of study drug) medications or herbal supplements known to be potent inhibitors of CYP3A or CYP2C19 must stop at least 1 week prior to taking MSC2490484A. Subjects receiving potent inducers of CYP3A or CYP2C19 must stop at least 3 weeks prior to taking MSC2490484A. Those receiving drugs mainly metabolized by CYP3A with a narrow
therapeutic index as judged by the Investigator (and after optional consultation with the Sponsor) must stop at least one day prior to taking MSC2490484A.
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